The combination of vitamin D / magnesium / vitamin B12 in patients older COVID-19 is associated with a significant reduction in the proportion of patients with clinical deterioration requiring oxygen.
Vitamin D, through its effect on the nuclear factor-kB can attenuate several proinflammatory cytokines in mediating the cytokine storm uncontrolled observed in severe cases of COVID-19 with deficiency associated with COVID-19 serious.
Magnesium is essential in the synthesis and activation of vitamin D, as a cofactor in many of the enzymes involved in the metabolism of vitamin D.
Vitamin B12 is essential to support the microbiome gut healthy, which has an important role in the development and function of immune systems, innate and adaptive.